David Magley's men, who were down by 24 points at the half, brought the London Lightning to within one point (with just 3.9 seconds left) before falling 118-113 on Tuesday at the Powerade Centre.
A missed free-throw by Cavell Johnson left Brampton down by one, and unable to win once again this season.
The A's are now 0-4 on the year, while London sit at a record of 3-1.
Richard Amardi lead the game with 34 points, and lead Brampton with eight rebounds. On London, Emmanuel Little finished the game with 22 points and 11 rebounds. Marvin Phillips was right behind him with 17 points and ten boards. Check out stats from tonight's game here.
The A's will head to Mississauga to take on the Power on Thursday, while London get set to host the Island Storm on Saturday.
To watch the game again, checkout the embedded player below.